Taking 15 prefectures in Xinjiang as a sample, constructing the comprehensive evaluation index system of highway transportation system and regional economic system, employing the coupling coordination degree model, this paper empirically studies the coordinated degree of highway transportation and regional economic development in Xinjiang cities from 2010 to 2014. The results show that the road transportation and regional economy in Xinjiang have a coupling development relationship. And the coupling coordination degree increases year by year,however, the overall coordination degree is lower. The coordination degree is highest in northern Xinjiang, Southern and Eastern Xinjiang are descending successively with many areas out of coordination. Finally, the corresponding recommendations are given in corresponding to the conclusions.