Based on elaborating the experience of international sub-regional cooperation model and mechanisms, this paper has analyzed the current cooperation status of “Sub-regional economic circle around the Altai Mountains”, proposing that Altai regional cooperation needs to upgrade cooperation model and improve cooperation mechanisms. So from macro-level,it puts concept of “a core area with three wings” border free trade zone cooperation model. From micro-level, it puts forward five kinds of cross-border cooperation mode for enterprises to choose, and suggests building the China-Russia-Mongolia-Kazakhstan “Four-country and Six-party” multi-layer dialogue mechanism, Xinjiang participating in the decision-making and consultation of “Sub-regional economic circle around the Altai Mountain”, in dispute settlement mechanism, in the implementation of economic cooperation mechanism and in information exchange mechanism.