In the era the Internet,cross-border e-commerce became an important part of modern service trade. This paper, based on the background of “Silk Road Economic Belt”,analyzes the status quo,problems and favorable conditions of the development of cross-border e-commerce in Xinjiang and holds that it has trouble in such aspects as talent, cross-border payments, international logistics,but it also has such favorable conditions as the policy support, “Five Big Centers” construction, small language rich talent pool,increasingly perfect international logistics transportation system,multilingual talents,studying abroad interactive education, the market effect and publicity effect of workers mutual flow, and so on. Therefore, it is suggested that weshould promote the development of cross-border e-commerce in Xinjiang through strengtheningpersonnel training,motivating the central Asian expansion of China's banking sector,Accelerating the process of cross-border electricity goods customs clearance facilitation,etc.