The digital economy promotes the coordinated development of various industries by promoting the transformation of production technology, restructuring the industrial model and upgrading the modernization level of the industrial chain, which provides realistic possibilities for the development of the traditional economy to the diversified economy. The development of the digital economy is an important strategic deployment made by the Party and the state to focus on the new situation of economic development and change. In this context, in the process of high-quality economic development in Xinjiang, there are still problems such as backward infrastructure, unbalanced industrial structure, lagging digital industry technology, and shortage of interdisciplinary talents. It is urgent to strengthen policy support and infrastructure construction, build industrial transformation and upgrading system, accelerate digital industry research and development, break disciplinary barriers, and strengthen talent introduction. Make the digital economy contribute to the high-quality economic development of Xinjiang. Therefore, this paper takes the construction of "eight industrial clusters" in Xinjiang as the entry point, combines digital economy with high-quality economic development in Xinjiang, further studies the important role of digital economy in high-quality economic development in Xinjiang, analyzes the difficulties in the construction of "eight industrial clusters" in Xinjiang under the background of digital economy, and further explores the specific path of high-quality economic development in Xinjiang.