The development of Eurasian transport and trade facilitation has important practical significance for the construction of the “Silk Road Economic Belt”. This paper makes an analysis and comparison of the transport and trade facilitation cooperation mechanisms under SPECA, TRACECA, the Euro-Asia Economic Union and CAREC and Shanghai Cooperation Organization. The studies suggest that the above mentioned cooperation mechanism have obvious differences and overlapping factors, and it is of necessity to pay attention to synergies between the various cooperation mechanisms. CAREC achieved remarkable results among them and will continue to dominate the construction of Eurasia regional transport corridor. As a result, the paper proposes to strengthen cooperation between “Silk Road Economic Belt” and CAREC in the areas of transport facilitation and trade facilitation. It is also recommended to take advantage of technical and financial support of international organizations and institutions to improve the construction of Eurasian consistent standards.