Based on the concept of high quality development, this paper constructs the evaluation index system of tourism industry,regional economy and ecological environment. Taking five provinces and regions in northwest China as an example, the comprehensive development index of each region and system from 2010 to 2019 was synthesized to evaluate its coupling coordination degree. The conclusions are as follows: during the study period, the tourism industry grew significantly, with the index value of up to 0.87 in 2019; the comprehensive development level of regional economy is relatively low, and the average value of the index fluctuates within 0.44 to 0.54. The overall development trend of ecological environment in all five provinces and regions is consistent. The coupling coordination degree of the three systems was nearly out of balance in 2010 to good coordination in 2019 with the index rose from 0.47 to 0.83. The scissors difference analysis shows that the evolution rate gap between the two systems is gradually narrowing, and there is a trend of coordinated evolution. In view of this, it is of great necessity for these five provinces and autonomous regions to take their advantages of location and policy to promote economic development and infrastructure construction based on the concept of coordinated development of regional integration, strengthen ecological protection and environmental supervision and governance, and create a friendly development featuring regional mutual assistance, symbiosis and mutual benefit.